Blossoc

Blossoc is a Linkage disequilibrium association mapping tool that attempts to build (perfect) genealogies for each site in the input and score these according to non-random clustering of affected individuals, and Judge high-scoring areas as likely candidates for containing disease affecting variation.Building the local genealogy trees is based on a number of heuristics that are not guaranteed to build true trees, but have the advantage over more sophisticated methods of being extremely fast. Blossoc can therefore handle much larger datasets than more sophisticated tools, but at the cost of sacrificing some accuracy.The mapping method implemented in Blossoc is described in: Whole genome association mapping by incompatibilities and local perfect phylogenies T. Mailund, S. Besenbacher and M.H. Schierup BMC Bioinformatics 2006 7(454). doi:10.1186/1471-2105-7-454. Local phylogeny mapping of quantitative traits: Higher accuracy and better ranking than single marker association in genomewide scans S. Besenbacher, T. Mailund and M.H. Schierup Genetics 181 747-753 2009; doi:10.1534/genetics.108.092643 See also Comparison of analyses of the QTLMAS XII common dataset. II: genome-wide association and fine mapping L. Crooks, G. Sahana, D-J de Koning, M.S. Lund and O. Carlborg BMC Proceedings 2009, 3(Suppl 1):S2 Data modeling as a main source of discrepancies in single and multiple marker association methods M.C. Ledur, N. Navarro and M. Perez-Enciso BMC Proceedings 2009, 3(Suppl 1):S2 Blossoc is released under the GNU General Public License.